Albendazole (Albenza) – worming agent of a wide range of activities.
Active ingredient: Albendazole http://rxwebdrugs.com/2013/03/22/albenza-albendazole/
Suspension for oral administration.
Mode of action of albendazole
Albenza – anthelmintic (worming), the product of a wide range of actions, derivative of benzimidazole carbamate. Albendazole is similar in structure to mebendazole http://westerndrugsdirect.com/vermox/.
The main mechanism of action of albendazole associated with selective inhibition of beta-tubulin polymerization, which leads to destruction of the intestinal cell cytoplasmic microtubules helminths.
Albendazole (Albenza) changes the course of biochemical actions: inhibits glucose utilization and inhibits the synthesis of ATP, blocks the movement of secretory granules and other organelles in the muscle cells of the round worm, causing their death.
Albendazole is particularly effective against the larval forms of cestodes – Echinococcus granulosus and Taenia solium, nematodes – Strongyloides stercolatis.
Albendazole effective both in mono-and poliinvaziyah.
The pharmacokinetics of albendazole
Upon receiving Albenzaa inwardly albendazole poorly absorbed from the gastrointestinal tract, in an unmodified form is not determined in the plasma, as is rapidly converted in the liver into a primary metabolite – albendazole sulfoxide as possessing anthelmintic activity.
Bioavailability in Albenzaa low. Admission fatty food increases the absorption and Cmax of albendazole to 5 times. Time merits Cmax of albendazole sulfoxide is 2-5 hours Associated with plasma proteins is 70%.
In fact, it is distributed throughout the body, is in the urine, bile, liver, and in the wall of cysts and cystic water, cerebrospinal fluid. Seeps into the wall and water cyst worms. Albendazole sulfoxide is metabolized to albendazole sulfone (secondary metabolite) and other oxidation products. T1 / 2 of albendazole sulfoxide – 8-12 hours
Excreted in the bile through the intestinal tract in the form of the active metabolite of albendazole sulfoxide, it is only a small amount is excreted in the urine. Ground clearance is not changed in patients with impaired renal function. When liver damage is increased bioavailability, with all this Cmax of albendazole sulfoxide increase in 2 times, and T1 / 2 is extended. Albendazole is a microsomal enzyme inducer of cytochrome P-450 (IA); accelerates the metabolism of nearly all pharmaceuticals.
Albendazole is used for worm infestations, including nematodoses 400 mg Tablets
A suspension for oral administration in a vial of 20 ml (400 mg).